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[48,49] . 근위-원위 축을 따라 해부학적 연구에서는 근위부와 원위부를 구분하는 전체 두께, 세포 밀도 및 내부 구조의 위치 의존적 변화가 보고되었습니다 [48,49] . 특히, 이 연구는 쥐와 생쥐 모두에서 'prosubiculum'이라고 불리는 주요 영역을 식별하는데, 이는 주로 세포 구조적 특징과 CA1과 subiculum 사이의 위치로 구별됩니다 [50–52] . 표면-심부 축에서 subiculum의 가장 깊은 층은 다형성 층이며, 이는 피라미드 층 아래에 위치하고 세포 밀도가 낮고 이질적인('다형성') 신경 세포 형태를 특징으로 합니다 [47] . 설치류 해마하부의 이질적인 분자적 환경 이러한 해마하부 세포구조의 변이는 서로 다른 유형의 흥분성 뉴런을 시사합니다. 이와 일관되게, 쥐와 생쥐 모두에서 세포구조 하위 영역은 여러 개별 마커의 면역조직화학적 염색을 통해 표지되는 것으로 나타났습니다 [50,53] . 최근 쥐를 대상으로 한 단일 세포 RNA 시퀀싱 연구에서는 이러한 세포구조 하위 영역과 관련된 유전자의 차별적 발현을 나타내는 다양한 흥분성 뉴런 하위 유형이 확인되었으며 [54] , 게놈 전체 현장 혼성화 데이터 [55] 는 이러한 마커 유전자를 기반으로 해부학적으로 구별되고 겹치지 않는 하위 영역을 확인했습니다 [16,18,51,54,56,57] . 이 연구는 해마하부가 세포적으로 균일한 구조가 아니며, 적어도 분자 수준에서는 개별적인 아형 특이적 이질성을 나타낸다는 사실을 밝히는 데 중요한 첫걸음이었습니다( 그림 2 A–F). <a class="seoquake-nofollow" href="https://zzgtv.com" rel="nofollow noreferrer noopener" style="font-size:0;line-height:0;text-decoration:none;" target="_blank"> <span 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